Search results for " Well-being"
showing 10 items of 797 documents
Genetic and phenotypic variation of the malaria vector Anopheles atroparvus in southern Europe
2011
Abstract Background There is a growing concern that global climate change will affect the potential for pathogen transmission by insect species that are vectors of human diseases. One of these species is the former European malaria vector, Anopheles atroparvus. Levels of population differentiation of An. atroparvus from southern Europe were characterized as a first attempt to elucidate patterns of population structure of this former malaria vector. Results are discussed in light of a hypothetical situation of re-establishment of malaria transmission. Methods Genetic and phenotypic variation was analysed in nine mosquito samples collected from five European countries, using eight microsatell…
User experiences of a mobile mental well-being intervention among pregnant women
2016
Postnatal depression affects 10 to 15 percent of women after childbirth. Acceptance and commitment therapy (ACT) is associated with better mental well-being and lower levels of depression. Digital ACT solutions enable providing potentially cost-effective access to interventions. This paper reports the user experiences of an ACT-based mobile mental well-being intervention among pregnant women. Twenty-nine mothers were recruited to a 6-month study. Usage rates were collected via usage logs and user experiences via questionnaires and interviews. The total usage time of the application was about 53 min per user. The application was perceived easy to use. The most common barriers of use were: co…
Enhancing Disaster Response for Hazardous Materials Using Emerging Technologies: The Role of AI and a Research Agenda
2019
Despite all efforts like the introduction of new training methods and personal protective equipment, the need to reduce the number of First Responders (FRs) fatalities and injuries remains. Reports show that advances in technology have not yet resulted in protecting FRs from injuries, health impacts, and odorless toxic gases effectively. Currently, there are emerging technologies that can be exploited and applied in emergency management settings to improve FRs protection. The aim of this paper is threefold: First, to conduct scenario analysis and situations that currently threat the first responders. Second, to conduct gap analysis concerning the new technology needs in relations to the pro…
What Are the Success Factors of Multilingual Families? Relationships Between Linguistic Attitudes and Community Dynamics
2021
The research focuses on the influence of emotional, cognitive, and social climate on the language choices of multilingual families, and the impact they can have on their general well-being, intergenerational relationships, and the community context. The methodological framework of reference is Grounded Theory. Collected data concern language practices, attitudes, emotions, and generational, trigenerational, and social interactive dynamics of multilingual families. The results include key insights into the variables underlying the linguistic attitudes of multicultural families. Two Network Views suggest that linguistic attitudes, such as the conscious management of specific and complex dynam…
Adjuvant chemotherapy and relative survival of patients with stage II colon cancer - A EURECCA international comparison between the Netherlands, Denm…
2016
BACKGROUND: The aim of the present EURECCA international comparison is to compare adjuvant chemotherapy and relative survival of patients with stage II colon cancer between European countries.METHODS: Population-based national cohort data (2004-2009) from the Netherlands (NL), Denmark (DK), Sweden (SE), England (ENG), Ireland (IE), and Belgium (BE) were obtained, as well as single-centre data from Lithuania. All surgically treated patients with stage II colon cancer were included. The proportion of patients receiving adjuvant chemotherapy was calculated and compared between countries. Besides, relative survival was calculated and compared between countries.RESULTS: Overall, 59,154 patients …
Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
2018
PubMed: 29599078
Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification
2016
Cancer is associated with strong changes in lipid metabolism. For instance, normal cells take up fatty acids (FAs) from the circulation, while tumour cells generate their own and become dependent on de novo FA synthesis, which could provide a vulnerability to target tumour cells. Betulinic acid (BetA) is a natural compound that selectively kills tumour cells through an ill-defined mechanism that is independent of BAX and BAK, but depends on mitochondrial permeability transition-pore opening. Here we unravel this pathway and show that BetA inhibits the activity of steroyl-CoA-desaturase (SCD-1). This enzyme is overexpressed in tumour cells and critically important for cells that utilize de n…
Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2
2021
Protein accumulation is the hallmark of various neuronal, muscular, and other human disorders. It is also often seen in the liver as a major protein-secretory organ. For example, aggregation of mutated alpha1-antitrypsin (AAT), referred to as PiZ, is a characteristic feature of AAT deficiency, whereas retention of hepatitis B surface protein (HBs) is found in chronic hepatitis B (CHB) infection. We investigated the interaction of both proteotoxic stresses in humans and mice. Animals overexpressing both PiZ and HBs (HBs-PiZ mice) had greater liver injury, steatosis, and fibrosis. Later they exhibited higher hepatocellular carcinoma load and a more aggressive tumor subtype. Although PiZ and H…
Genetic association study of childhood aggression across raters, instruments, and age
2021
AbstractChildhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three sign…
Molecular surveillance of norovirus, 2005–16 : an epidemiological analysis of data collected from the NoroNet network
2018
BACKGROUND: The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network.METHODS: We included genetic sequences of norovirus specimens obtained from outbreak investigations and sporadic gastroenteritis cases between 2005 and 2016 in Europe, Asia, Oceania, and Africa. We genotyped norovirus sequences and analysed sequences that overlapped at open reading frame (ORF) 1 and ORF2. Additionally, we assessed the sampling date and country of origin of the first reported sequence to assess when and where novel drift variants originated.FINDINGS: W…